Mesothelioma, more clearly malignant Mesothelioma, is a rare type of cancer, which arises from the protective layer covering the many internal organs of the body, the mesothelioma. This disease is usually caused by exposure to asbestos.
Plura (the exterior of the inner part of the lungs and chest) is the most common place for this disease, but it is peritoneum (abdominal cover), heart, pericardium or tunica vaginalis ).
Most of the people suffering from mesothelioma were either working in areas where asbestos and glass particles entered their body during respiration or they came in contact with asbestos particles and fibers in other ways. It has also been expressed in the likelihood that the washing of a family member working with asbestos or glass may also cause the risk of developing mesothelioma in a person. , Unlike lung cancer, mesothelioma and There is no connection between smoking, but the risk of asbestos-induced other cancers is greatly increased due to smoking. Contact with asbestos Many people who have come to asbestos-related diseases, including mesothelioma, have often been taking the help of lawyers to get compensation. The compensation received through asbestos funds or legal lawsuits is an important issue in mesothelioma (see asbestos and law).
Symptoms of mesothelioma include pleural leakage (fluid between the lungs and chest wall) or pain in the chest due to shortness of breath and general symptoms, such as weight loss. Its diagnosis can be estimated by chest x-ray and CT scan, and it can be confirmed by biopsy (samples of tissues) and microscopic test. Thoracoscopy (chemically inserting a tube on the chest) can be used to take a biopsy. It also allows the use of substances such as talc to wipe the pleural part (which is called pleurodesis), to prevent further fluid accumulation and pressure on the lungs. Despite the treatment done by chemotherapy, radiation therapy, and sometimes surgery, diagnosis of this disease can be very rare. Research is ongoing for screening tests for early detection of mesothelioma.
Signs and symptoms
It is possible that signs and symptoms of mesothelioma may not appear for 20 to 50 years even after exposure to asbestos. Problems in breathing, cough and chest pain are often symptoms of pleural mesothelioma due to the accumulation of fluid in the pleural space (pleural rigs).
Symptoms of peritoneal mesothelioma include weight gain and cachexia, abdominal bloating and pain due to ascites (a fluid formed in the abdomen). Other symptoms of peritoneal mesothelioma may include obstruction of intestines, problems in blood clotting, anemia, and fever. If cancer has spread beyond the mesothelium to other parts of the body, then its symptoms may include pain, swallowing, and swelling on the neck or face.
These symptoms may have arisen due to mesothelioma or other, less severe conditions.
Mesothelioma that affects the pleura can cause these signs and symptoms:
- Chest pain
- Lungs from the lungs, or solidification of fluid around the lungs
- Shortness of breath
- Fatigue or anemia
- Wheezing, hoarseness, or cough
- Blood in the sputum (fluid) coming out of cough (hemoptysis)
In severe cases, the tumor may also occur in a person’s body. The situation may also arise in the person to stop work by pneumothorax, or lungs. The disease can increase and spread to other parts of the body.
Tumors affecting the stomach normally do not cause any symptoms until they reach the very later stage. Symptoms include:
Abnormal congestion of fluid in the abdomen
Problems with intestinal functions
In severe cases of the disease, the following signs and symptoms may exist:
Blood clots in the veins, which can cause thrombophlebitis
Disinfected intravascular coagulation, a problem that causes severe bleeding in many organs of the body
Jaundice, or yellowing in eyes and skin
The decrease in blood glucose levels
Leakage in the lungs
Blood clotting in the pulmonary emboli, or lung arteries
Usually, mesothelioma does not spread to the bones, brain or adrenal gland. Lung tumors are commonly found only on one side of the lungs.
Reasons for mesothelioma
Working with asbestos is a major risk factor for mesothelioma. In the United States, asbestos is the leading cause of malignant mesothelioma and is thought to be associated with the development of mesothelioma in “undisputed”. In fact, the connection between asbestos and mesothelioma is so deep that many people consider mesothelioma as a “signal” or “sentinel” tumor. In most cases, History of contact with asbestos is found. However, some people have been reported to have mesothelioma without any known contact with asbestos. In rare cases, mesothelioma has also been seen by connecting radiation therapy, intrapleural thorium dioxide (Thorotrast) and other fibrous silicates, such as Aronitis. Some studies show that Symposium Virus SV40 may be working as a helpful factor in the development of mesothelioma.
Asbestos was also known in ancient times, but it was not extracted from mines until the nineteenth century and commercially it was not used extensively. Its use increased greatly during World War II. Since the beginning of the 1940s, millions of American laborers had been exposed to asbestos particles. Initially, the information about the risks of exposure to asbestos was not available publicly. However, later it was found that the risk of developing mesothelioma in shipbuilding factories, people working in asbestos mines and mills, growers of asbestos products, workers of the heating and construction industries and other business people are very much involved. Today the official approach of the United States’s Occupational Safety and Health Administration (OHA [OSHA]) and the EPA of the United States is that the safety criteria and “permissible contact limitations” required by US laws, although asbestos- Most of the non-incurable diseases are adequate to prevent, but still they may cause asbestos-related cancers, such as mesothelioma, Similarly, the British Government’s Health and Safety Executive (HSE) has formally said that no limit on mesothelioma is enough It should be at the lower level and it is widely accepted that even if such a limit exists, then it can not be quantified at present. So for practical purposes, HSE assumes that no “safe” range exists. Other people have also found that there is no evidence of the presence of such a border under which there is no risk of mesothelioma. It appears that there is a linear relationship between the drug’s dose and its reaction, according to which the increase in the dose of the disease increases the disease. Despite this, mesothelioma may be abnormal, low-level or asbestos Indirect contact can be linked to. It appears that the amount of dosage needed for effect is asbestos-pus compared to pulmonary asbestosis or lung cancer. Rerit decrease for mesothelioma. Again, there is exposure to asbestos is no known safe level because it is associated with an increased risk of mesothelioma.
The period of exposure to asbestos can be shortened to produce mesothelioma. For example, cases of mesothelioma arising out of 1-3 months of contact have been documented.People working with asbestos wear personal protective equipment to do the risk associated with it.
The length of latency, from the first contact to the emergence of the disease, is longer in the case of mesothelioma. It is almost never less than fifteen years, while its maximum level is 30-40 years. In a review of the cases of mesothelioma related to business, the mean of the latency period was 32 years. Peto and others Based on the data obtained from Peto et al, the risk of mesothelioma appears to increase from the first contact to the third or fourth power.
It has been found that cases of mesothelioma are seen in people living near those places where asbestos is found naturally. For example, in the central Cappadocia, Turkey, 50% of all the deaths in three small villages-Tuzköy, Karain and Sarıhıdır-were due to mesothelioma. Initially, a hydroxide mineral with symptoms such as aeronaut, asbestos, was considered to be the cause, although in recent pandemic detailed tests it was found that aeronitis mostly causes mesothelioma in those families, which have a genetic tendency. Due to the presence of asbestos fibers in the supply of water and food items, in the long run, and yet, there has been concern about the possible effects of unknown fertility on these fibers.
Contact with asbestos fibers has been recognized as a business health risk since the beginning of the twentieth century. Many pandemic-related studies have linked the commercial contact of asbestos to lung plaque, lung transplantation, asbestosis, lungs and laryngeal cancer, gastrointestinal tumor and lung cavity and malignant mesothelioma of the peritoneum. Asbestos has been used extensively in many industrial products, including cement brake lining, gasket, roof frames, floor related products, textile, and insulation.
Commercial excavation of asbestos occurred between 1945 and 1966 in the White norm, Western Australia. According to a collective study of mining personnel working in the mine, however, after contact with crocidolite, no one died in the first 10 years, but in 1985 there were 80 deaths, which could be seen by connecting to mesothelioma. By 1994, 539 deaths were reported from mesothelioma in Western Australia.
Paraprofessional secondary contact
The risk of mesothelioma and possibly other asbestos-related diseases is also increased in the family of asbestos workers and others living with them. This risk increases asbestos workers’ clothing and hair, and they come home with asbestos Dust could be the result. In order to reduce the likelihood of exposure of asbestos fibers to family members, it is often necessary for asbestos workers to take a bath and change clothes before leaving their workplace.
Asbestos in buildings
There may be asbestos in many building materials used in both public and private premises before banning asbestos. People doing repair work or DIY activities may be exposed to asbestos. In the UK, the use of chrysotile asbestos was banned at the end of 1999. Brown and blue asbestos were banned in the UK in the year 1985. Build or renovated buildings before these dates may contain asbestos contents.